An evolving form of treatment which emphases on alternative drug delivery is nanomedicine. It reduces unfavourable side effects to normal tissues and progresses the efficacy of treatment. Resistance towards cancer drug treatment is a complicated process that comprises of numerous mechanisms. To overcome these treatment complications and the major forms of drug resistance these nanomedicine provides new possibilities. These novel nanomedicines have a fast drug design, flexible and production based on genetic profiles of tumour. To overcome various forms of multi-drug resistance different nano drugs looks hopeful. As well as new prospects for cancer treatment alternative mechanisms of drug delivery and advanced designs are to proven to be worth full in overcoming, production based on genetic profiles of tumour. For overcoming cancer drug resistance, the current study aims to show the lead of nanomedicine in the medical science arena.